Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rosalie Sears
PROVIDER: E-GEOD-33776 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Farrell Amy S AS Pelz Carl C Wang Xiaoyan X Daniel Colin J CJ Wang Zhiping Z Su Yulong Y Janghorban Mahnaz M Zhang Xiaoli X Morgan Charlie C Impey Soren S Sears Rosalie C RC
Molecular and cellular biology 20130528 15
The Myc oncoprotein is considered a master regulator of gene transcription by virtue of its ability to modulate the expression of a large percentage of all genes. However, mechanisms that direct Myc's recruitment to DNA and target gene selection to elicit specific cellular functions have not been well elucidated. Here, we report that the Pin1 prolyl isomerase enhances recruitment of serine 62-phosphorylated Myc and its coactivators to select promoters during gene activation, followed by promotin ...[more]