Unknown,Transcriptomics,Genomics,Proteomics

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A novel post-translational mechanism controlling the oncogenic activity of c-Myc is enhanced in poor outcome breast cancer


ABSTRACT: Examination of Pin1-regulated Myc target genes in a human breast epithelial cell line. Two samples: control GFP-expressing MCF10A-Myc cells and Pin1-expressing MCF10A-Myc cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Rosalie Sears 

PROVIDER: E-GEOD-33776 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Farrell Amy S AS   Pelz Carl C   Wang Xiaoyan X   Daniel Colin J CJ   Wang Zhiping Z   Su Yulong Y   Janghorban Mahnaz M   Zhang Xiaoli X   Morgan Charlie C   Impey Soren S   Sears Rosalie C RC  

Molecular and cellular biology 20130528 15


The Myc oncoprotein is considered a master regulator of gene transcription by virtue of its ability to modulate the expression of a large percentage of all genes. However, mechanisms that direct Myc's recruitment to DNA and target gene selection to elicit specific cellular functions have not been well elucidated. Here, we report that the Pin1 prolyl isomerase enhances recruitment of serine 62-phosphorylated Myc and its coactivators to select promoters during gene activation, followed by promotin  ...[more]

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