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Transcription profiling of different sub-types of mouse dendritic cells to study the functional relationships and properties of these cells.

ABSTRACT: The functional relationships and properties of different sub-types of dendritic cells (DC) remain largely undefined. We used a global gene profiling approach to determine gene expression patterns among murine splenic CD11c high DC subsets in an effort to better characterise these cells.

ORGANISM(S): Mus musculus

SUBMITTER: Damien Chaussabel

PROVIDER: E-GEOD-339 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns.

Edwards Alexander D AD Chaussabel Damien D Tomlinson Simon S Schulz Oliver O Sher Alan A Reis e Sousa Caetano C

Journal of immunology (Baltimore, Md. : 1950) 20030701 1

The functional relationships and properties of different subtypes of dendritic cells (DC) remain largely undefined. To better characterize these cells, we used global gene analysis to determine gene expression patterns among murine CD11c(high) DC subsets. CD4(+), CD8alpha(+), and CD8alpha(-) CD4(-) (double negative (DN)) DC were purified from spleens of normal C57/BL6 mice and analyzed using Affymetrix microarrays. The CD4(+) and CD8alpha(+) DC subsets showed distinct basal expression profiles d ...[more]

PMID: 12816982

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