COMPARATIVE TRANSCRIPTOMIC AND PROTEOMIC ANALYSIS OF LGR5+ve STEM CELLS AND THEIR DAUGHTERS
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Stange
PROVIDER: E-GEOD-33949 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.
Schepers Arnout G AG Snippert Hugo J HJ Stange Daniel E DE van den Born Maaike M van Es Johan H JH van de Wetering Marc M Clevers Hans H
Science (New York, N.Y.) 20120801 6095
The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer. By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrim ...[more]
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