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Early responding dendritic cells direct local natural killer response to control HSV-1 infection within the cornea

ABSTRACT: Dendritic cells (DCs) regulate both innate and adaptive immune responses. The role of CD11c-plus DCs in the corneal response to to herpes simplex virus-1 (HSV-1) infection was investigated by depleting them prior to infection. Bone marrow cells from CD11c-DTR (C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J) mice were transferred intravenously to irradiated BALB/cJ host mice. After 6 weeks, the bone marrow chimeric host mice were injected with diphtheria toxin (DT) to deplete CD11c-positive cells. Two days after injection, the mice were subjected to a standard corneal infection protocol using HSV-1.

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Harvey

PROVIDER: E-GEOD-33991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early responding dendritic cells direct local natural killer response to control HSV-1 infection within the cornea

Project description:Dendritic cells (DCs) regulate both innate and adaptive immune responses. The role of CD11c-plus DCs in the corneal response to to herpes simplex virus-1 (HSV-1) infection was investigated by depleting them prior to infection.

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Inflammation switches the differentiation program of Ly6Chi monocytes from anti-inflammatory macrophages to inflammatory dendritic cells in the colon

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