Proteomics

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The antiviral protein IFIX is targeted for degradation during HSV-1 infection


ABSTRACT: IFIX has been shown to be an antiviral factor druing HSV-1 infection. Here we define a mechanism by which IFIX exerts it antiviral function and discover a means by which the virus target IFIX to inhibit this function.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Marni Crow  

LAB HEAD: Ileana Cristea

PROVIDER: PXD005152 | Pride | 2017-01-16

REPOSITORIES: Pride

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Publications

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

Crow Marni S MS   Cristea Ileana M IM  

Molecular & cellular proteomics : MCP 20170111 4 suppl 1


The interferon-inducible protein X (IFIX), a member of the PYHIN family, was recently recognized as an antiviral factor against infection with herpes simplex virus 1 (HSV-1). IFIX binds viral DNA upon infection and promotes expression of antiviral cytokines. How IFIX exerts its host defense functions and whether it is inhibited by the virus remain unknown. Here, we integrated live cell microscopy, proteomics, IFIX domain characterization, and molecular virology to investigate IFIX regulation and  ...[more]

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