Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Marni Crow
LAB HEAD: Ileana Cristea
PROVIDER: PXD005152 | Pride | 2017-01-16
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 64 |
Crow Marni S MS Cristea Ileana M IM
Molecular & cellular proteomics : MCP 20170111 4 suppl 1
The interferon-inducible protein X (IFIX), a member of the PYHIN family, was recently recognized as an antiviral factor against infection with herpes simplex virus 1 (HSV-1). IFIX binds viral DNA upon infection and promotes expression of antiviral cytokines. How IFIX exerts its host defense functions and whether it is inhibited by the virus remain unknown. Here, we integrated live cell microscopy, proteomics, IFIX domain characterization, and molecular virology to investigate IFIX regulation and ...[more]