Prp4-1 temperature shift
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tyson Clark
PROVIDER: E-GEOD-34 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays.
Clark Tyson A TA Sugnet Charles W CW Ares Manuel M
Science (New York, N.Y.) 20020501 5569
Introns interrupt almost every eukaryotic protein-coding gene, yet how the splicing apparatus interprets the genome during messenger RNA (mRNA) synthesis is poorly understood. We designed microarrays to distinguish spliced from unspliced RNA for each intron-containing yeast gene and measured genomewide effects on splicing caused by loss of 18 different mRNA processing factors. After accommodating changes in transcription and decay by using gene-specific indexes, functional relationships between ...[more]
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