Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Victor Segura
PROVIDER: E-GEOD-34015 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vicente-Dueñas Carolina C Fontán Lorena L Gonzalez-Herrero Ines I Romero-Camarero Isabel I Segura Victor V Aznar M Angela MA Alonso-Escudero Esther E Campos-Sanchez Elena E Ruiz-Roca Lucía L Barajas-Diego Marcos M Sagardoy Ainara A Martinez-Ferrandis Jose I JI Abollo-Jimenez Fernando F Bertolo Cristina C Peñuelas Ivan I Garcia-Criado Francisco J FJ García-Cenador María B MB Tousseyn Thomas T Agirre Xabier X Prosper Felipe F Garcia-Bragado Federico F McPhail Ellen D ED Lossos Izidore S IS Du Ming-Qing MQ Flores Teresa T Hernandez-Rivas Jesus M JM Gonzalez Marcos M Salar Antonio A Bellosillo Beatriz B Conde Eulogio E Siebert Reiner R Sagaert Xavier X Cobaleda Cesar C Sanchez-Garcia Isidro I Martinez-Climent Jose A JA
Proceedings of the National Academy of Sciences of the United States of America 20120611 26
Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1(+)Lin(-) hematopoietic stem/progenitor cells, which showed NF-κB activation and early lymphoid priming, being selectively skewed toward B-cell differentiation. These cells accumulated in extranodal tissues and gave rise to clonal tumors ...[more]