Genome-wide maps of Yan chromatin association
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Ilaria Rebay
PROVIDER: E-GEOD-34040 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan.
Webber Jemma L JL Zhang Jie J Cote Lauren L Vivekanand Pavithra P Ni Xiaochun X Zhou Jie J Nègre Nicolas N Carthew Richard W RW White Kevin P KP Rebay Ilaria I
Genetics 20121119 2
ETS family transcription factors are evolutionarily conserved downstream effectors of Ras/MAPK signaling with critical roles in development and cancer. In Drosophila, the ETS repressor Yan regulates cell proliferation and differentiation in a variety of tissues; however, the mechanisms of Yan-mediated repression are not well understood and only a few direct target genes have been identified. Yan, like its human ortholog TEL1, self-associates through an N-terminal sterile α-motif (SAM), leading t ...[more]
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