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Transcription profiling of allograft and isograft mouse heterotopic trachea to study murine obliterative airway disease.

ABSTRACT: Exploration of genes associated with acute and chronic rejection associated with obliterative airway disease Experiment Overall Design: Untransplanted trachea (controls; n=5) and trachea transplanted into MHC compatible/incompatible recipients at day 4 (n = 5 compatible/5 incompatible), day 14 (n = 5/5) or day 25 (n = 5/5)

ORGANISM(S): Mus musculus

SUBMITTER: Jeff Lande

PROVIDER: E-GEOD-3418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling in murine obliterative airway disease.

Lande Jeffrey D JD Dalheimer Stacy L SL Mueller Daniel L DL Hertz Marshall I MI King Richard A RA

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050901 9

Lung and heart-lung transplantation are effective treatments for many diseases unresponsive to other therapy. However, long-term survival of recipients is limited by the development of obliterative bronchiolitis (OB). In this study, microarray analysis of a heterotopic mouse model of obliterative airway disease (OAD) was used to test the hypothesis that the expression and patterns of genes will correlate with specific changes in tracheal tissue developing a response to allotransplantation and th ...[more]

PMID: 16095496

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