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Transcriptome study in rhesus monkey

ABSTRACT: Rhesus Monkey is one of the important primate models widely used in the fields of disease mechanism study, pre-clinical test in drug discovery and molecular evolution. However, the majority of rhesus gene annotations were putatively mapped from human genome, with only 10% supported by rhesus EST data.So, to better study the transcriptome, paired-end, strand-specific, poly(A)-positive RNA-Seq were performed in 5 rhesus monkey tissues. 5 tissue samples examined: prefrontal cortex, liver, skeletal muscle, adipose, testis

ORGANISM(S): Macaca mulatta

SUBMITTER: Jia-Yu Chen

PROVIDER: E-GEOD-34426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RhesusBase: a knowledgebase for the monkey research community.

Zhang Shi-Jian SJ Liu Chu-Jun CJ Shi Mingming M Kong Lei L Chen Jia-Yu JY Zhou Wei-Zhen WZ Zhu Xiaotong X Yu Peng P Wang Jue J Yang Xinzhuang X Hou Ning N Ye Zhiqiang Z Zhang Rongli R Xiao Ruiping R Zhang Xiuqin X Li Chuan-Yun CY

Nucleic acids research 20120910 Database issue

Although the rhesus macaque is a unique model for the translational study of human diseases, currently its use in biomedical research is still in its infant stage due to error-prone gene structures and limited annotations. Here, we present RhesusBase for the monkey research community (http://www.rhesusbase.org). We performed strand-specific RNA-Seq studies in 10 macaque tissues and generated 1.2 billion 90-bp paired-end reads, covering >97.4% of the putative exon in macaque transcripts annotated ...[more]

PMID: 22965133

Publication: 1/2

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