Gene Expression Signature Shared in Autoimmune Diseases Not in Unaffected Family Members

ABSTRACT: Even though autoimmune diseases are heterogeneous, believed to result from the interaction between genetic and environmental components, patients with these disorders exhibit reproducible patterns of gene expression in their peripheral blood mononuclear cells. A portion of this gene expression profile reflects family resemblance rather than the actual presence of an autoimmune disease. Here we wanted to identify that portion of this gene expression pattern that is independent of family resemblance and determine if it is a product of disease duration, disease onset, or other factors. By increasing the number of autoimmune samples in our analysis and employing supervised clustering algorithms, we identified 100 genes whose expression profiles are shared in individuals with various autoimmu

ORGANISM(S): Homo sapiens

SUBMITTER: Zheng Liu 

PROVIDER: E-GEOD-3447 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress