Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mi Cai
PROVIDER: E-GEOD-34583 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cai Mi M Langer Ellen M EM Gill Jennifer G JG Satpathy Ansuman T AT Albring Jörn C JC KC Wumesh W Murphy Theresa L TL Murphy Kenneth M KM
Blood 20120604 2
Myeloid ecotropic viral integration site 1 (Meis1) forms a heterodimer with Pbx1 that augments Hox-dependent gene expression and is associated with leukemogenesis and HSC self-renewal. Here we identified 2 independent actions of Meis1 in hematopoietic development: one regulating cellular proliferation and the other involved in megakaryocyte lineage development. First, we found that endogenous Mesp1 indirectly induces Meis1 and Meis2 in endothelial cells derived from embryonic stem cells. Overexp ...[more]