Unknown,Transcriptomics,Genomics,Proteomics

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Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE34537: Mesp1 induces a subset of hematopoietic-associated transcription factors in ES cell-derived Flk1+Tie2+ endothelium GSE34541: Identification of gene targets of Meis2 GSE34543: Identification of gene targets of Meis1 Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Mi Cai 

PROVIDER: E-GEOD-34583 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

Cai Mi M   Langer Ellen M EM   Gill Jennifer G JG   Satpathy Ansuman T AT   Albring Jörn C JC   KC Wumesh W   Murphy Theresa L TL   Murphy Kenneth M KM  

Blood 20120604 2


Myeloid ecotropic viral integration site 1 (Meis1) forms a heterodimer with Pbx1 that augments Hox-dependent gene expression and is associated with leukemogenesis and HSC self-renewal. Here we identified 2 independent actions of Meis1 in hematopoietic development: one regulating cellular proliferation and the other involved in megakaryocyte lineage development. First, we found that endogenous Mesp1 indirectly induces Meis1 and Meis2 in endothelial cells derived from embryonic stem cells. Overexp  ...[more]

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