Triiodothyronine Treatment: Effects on vastus lateralis skeletal muscle
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Karine Clement
PROVIDER: E-GEOD-3462 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
Clément Karine K Viguerie Nathalie N Diehn Maximilian M Alizadeh Ash A Barbe Pierre P Thalamas Claire C Storey John D JD Brown Patrick O PO Barsh Greg S GS Langin Dominique D
Genome research 20020201 2
Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss. Although the molecular actions of thyroid hormones have been studied thoroughly, their pleiotropic effects are mediated by complex changes in expression of an unknown number of target genes. Here, we measured patterns of skeletal muscle gene expression in five healthy men treated for 14 days with 75 m ...[more]
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