Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sami Heikkinen
PROVIDER: E-GEOD-34759 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Malinen Marjo M Jääskeläinen Tiina T Pelkonen Mikko M Heikkinen Sami S Väisänen Sami S Kosma Veli-Matti VM Nieminen Kaisa K Mannermaa Arto A Palvimo Jorma J JJ
Molecular and cellular endocrinology 20121106 2
We searched ERα cistromes of MCF-7 breast cancer cells for previously unrecognized ERα targets and identified proto-oncogene PIM-1 as a novel potential target gene. We show that the expression of PIM-1 is induced in response to estradiol in MCF-7 cells and that the induction is mediated by ERα-regulated enhancers located distally upstream from the gene. In keeping with the growth-promoting role of the PIM-1, depletion of the PIM-1 attenuated the proliferation of the MCF-7 cells, which was parall ...[more]