Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Binhua Zhou
PROVIDER: E-GEOD-34925 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dong Chenfang C Yuan Tingting T Wu Yadi Y Wang Yifan Y Fan Teresa W M TW Miriyala Sumitra S Lin Yiwei Y Yao Jun J Shi Jian J Kang Tiebang T Lorkiewicz Pawel P St Clair Daret D Hung Mien-Chie MC Evers B Mark BM Zhou Binhua P BP
Cancer cell 20130228 3
The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells with cancer stem cell (CSC)-like characteristics. We show that the Snail-G9a-Dnmt1 complex, which is critical for E-cadherin promoter silencing, is also required for the promoter methylation of fructose-1,6-biphosphatase (FBP1) in basal-like breast cancer (BLBC). Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and main ...[more]