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Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

ABSTRACT: We provide ChIP-Seq analysis of Egr2 and Sox10 transcription factor binding in Schwann cells of rat peripheral nerve ChIP-Seq analysis of Egr2 and Sox10 binding in P15 rat sciatic nerve. Wiggle files of negative log of posterior probability determined by Mosaics.

ORGANISM(S): Rattus norvegicus

SUBMITTER: John Svaren

PROVIDER: E-GEOD-35132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve.

Srinivasan Rajini R Sun Guannan G Keles Sunduz S Jones Erin A EA Jang Sung-Wook SW Krueger Courtney C Moran John J JJ Svaren John J

Nucleic acids research 20120409 14

Myelin is essential for the rapidity of saltatory nerve conduction, and also provides trophic support for axons to prevent axonal degeneration. Two critical determinants of myelination are SOX10 and EGR2/KROX20. SOX10 is required for specification of Schwann cells from neural crest, and is required at every stage of Schwann cell development. Egr2/Krox20 expression is activated by axonal signals in myelinating Schwann cells, and is required for cell cycle arrest and myelin formation. To elucidate ...[more]

PMID: 22492709

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