Transcriptional profiling of Lung H1299-BRG1 inducible cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Antonio Gomez
PROVIDER: E-GEOD-35168 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.
Romero Octavio A OA Setien Fernando F John Sam S Gimenez-Xavier Pol P Gómez-López Gonzalo G Pisano David D Condom Enric E Villanueva Alberto A Hager Gordon L GL Sanchez-Cespedes Montse M
EMBO molecular medicine 20120411 7
BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it is unclear how it promotes tumourigenesis. We report that re-expression of BRG1 in lung cancer cells up-regulates lung-specific transcripts, restoring the gene expression signature of normal lung. Using cell lines from several cancer types we found that those lacking BRG1 do not respond to retinoic acid (RA) or glucocorticoids (GC), while restoration of BRG1 restores sensitivity. Conversely, in SH-SY5Y cells, a paradigm of RA-de ...[more]
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