Infection of bone marrow derived macrophages with M. tuberculosis CDC1551
Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis H37Rv
SUBMITTER: Kyle Rohde
PROVIDER: E-GEOD-35362 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection.
Rohde Kyle H KH Veiga Diogo F T DF Caldwell Shannon S Balázsi Gábor G Russell David G DG
PLoS pathogens 20120621 6
Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for coping with the pressures encountered inside host cells. The ability to coordinate global gene expression in response to environmental and internal cues is one key to their success. Prolonged survival and replication within macrophages, a key virulence trait of M. tuberculosis, requires dynamic adaptation to diverse and changing conditions within its phagosomal niche. However, the physiological adaptations dur ...[more]
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