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Influenza virus A infected monocytes

ABSTRACT: Gene expression profiles 6 hours post-influenza A virus infection in human monocytes at multiplicities of infection of 10 versus uninfected monocytes total six samples - comparing uninfected and infected samples from three individual subjects

ORGANISM(S): Homo sapiens

SUBMITTER: Timothy Myers

PROVIDER: E-GEOD-35473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells.

Hou Wanqiu W Gibbs James S JS Lu Xiuju X Brooke Christopher B CB Roy Devika D Modlin Robert L RL Bennink Jack R JR Yewdell Jonathan W JW

Blood 20120206 13

Surprisingly little is known about the interaction of human blood mononuclear cells with viruses. Here, we show that monocytes are the predominant cell type infected when peripheral blood mononuclear cells are exposed to viruses ex vivo. Remarkably, infection with vesicular stomatitis virus, vaccinia virus, and a variety of influenza A viruses (including circulating swine-origin virus) induces monocytes to differentiate within 18 hours into CD16(-)CD83(+) mature dendritic cells with enhanced cap ...[more]

PMID: 22310910

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