Unknown,Transcriptomics,Genomics,Proteomics

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Lack of hepatic response of microRNA in mice following DB[a,h]A exposure


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Williams 

PROVIDER: E-GEOD-35509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene.

Malik Amal I AI   Rowan-Carroll Andrea A   Williams Andrew A   Lemieux Christine L CL   Long Alexandra S AS   Arlt Volker M VM   Phillips David H DH   White Paul A PA   Yauk Carole L CL   Yauk Carole L CL  

Mutagenesis 20130621 5


Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated the effects of DB[a,h]A on mRNA and microRNA expression to dissect the mechanisms involved in carcinogenesis. In this study, mature male mice (Muta(™)Mouse) were exposed to 6.25, 12.5 and 25mg/kg/day DB[a,h]A by oral gavage for 28 consecutive days. Results were compared with mice similarly exposed to benzo[a]pyrene (B[a]P) in our previous  ...[more]

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