Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Andrew Williams
PROVIDER: E-GEOD-35509 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Malik Amal I AI Rowan-Carroll Andrea A Williams Andrew A Lemieux Christine L CL Long Alexandra S AS Arlt Volker M VM Phillips David H DH White Paul A PA Yauk Carole L CL Yauk Carole L CL
Mutagenesis 20130621 5
Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated the effects of DB[a,h]A on mRNA and microRNA expression to dissect the mechanisms involved in carcinogenesis. In this study, mature male mice (Muta(™)Mouse) were exposed to 6.25, 12.5 and 25mg/kg/day DB[a,h]A by oral gavage for 28 consecutive days. Results were compared with mice similarly exposed to benzo[a]pyrene (B[a]P) in our previous ...[more]