Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mathias Hornef
PROVIDER: E-GEOD-35597 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pott Johanna J Stockinger Silvia S Torow Natalia N Smoczek Anna A Lindner Cornelia C McInerney Gerald G Bäckhed Fredrik F Baumann Ulrich U Pabst Oliver O Bleich André A Hornef Mathias W MW
PLoS pathogens 20120503 5
Rotavirus is a major cause of diarrhea worldwide and exhibits a pronounced small intestinal epithelial cell (IEC) tropism. Both human infants and neonatal mice are highly susceptible, whereas adult individuals remain asymptomatic and shed only low numbers of viral particles. Here we investigated age-dependent mechanisms of the intestinal epithelial innate immune response to rotavirus infection in an oral mouse infection model. Expression of the innate immune receptor for viral dsRNA, Toll-like r ...[more]