Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Frank
PROVIDER: E-GEOD-57919 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Camp J Gray JG Frank Christopher L CL Lickwar Colin R CR Guturu Harendra H Rube Tomas T Wenger Aaron M AM Chen Jenny J Bejerano Gill G Crawford Gregory E GE Rawls John F JF
Genome research 20140624 9
Microbiota regulate intestinal physiology by modifying host gene expression along the length of the intestine, but the underlying regulatory mechanisms remain unresolved. Transcriptional specificity occurs through interactions between transcription factors (TFs) and cis-regulatory regions (CRRs) characterized by nucleosome-depleted accessible chromatin. We profiled transcriptome and accessible chromatin landscapes in intestinal epithelial cells (IECs) from mice reared in the presence or absence ...[more]