Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hozumi Motohashi
PROVIDER: E-GEOD-35645 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fujita Rie R Takayama-Tsujimoto Mariko M Satoh Hironori H Gutiérrez Laura L Aburatani Hiroyuki H Fujii Satoshi S Sarai Akinori A Bresnick Emery H EH Yamamoto Masayuki M Motohashi Hozumi H
Molecular and cellular biology 20130506 14
NF-E2 is a heterodimeric transcription factor consisting of p45 and small Maf subunits. Since p45(-/-) mice display severe thrombocytopenia, p45 is recognized as a critical regulator of platelet production from megakaryocytes. To identify direct p45 target genes in megakaryocytes, we used chromatin immunoprecipitation (ChIP) sequencing to analyze the genome-wide chromatin occupancy of p45 in primary megakaryocytes. p45 target gene candidates obtained from the analysis are implicated in the produ ...[more]