Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Nancy Chen
PROVIDER: E-GEOD-35664 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jin Wen W Reddy Marpadga A MA Chen Zhuo Z Putta Sumanth S Lanting Linda L Kato Mitsuo M Park Jung Tak JT Chandra Manasa M Wang Charles C Tangirala Rajendra K RK Natarajan Rama R
The Journal of biological chemistry 20120319 19
Angiotensin II (Ang II)-mediated vascular smooth muscle cell dysfunction plays a critical role in cardiovascular diseases. However, the role of microRNAs (miRNAs) in this process is unclear. We used small RNA deep sequencing to profile Ang II-regulated miRNAs in rat vascular smooth muscle cells (VSMC) and evaluated their role in VSMC dysfunction. Sequencing results revealed several Ang II-responsive miRNAs, and bioinformatics analysis showed that their predicted targets can modulate biological p ...[more]