Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kyle Matthew Sousa
PROVIDER: E-GEOD-3571 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stem cells (Dayton, Ohio) 20061012 2
Nurr1 is an orphan nuclear receptor required for the development of midbrain dopaminergic neurons. To better understand the molecular consequences of Nurr1 expression, we compared the transcriptomes of two independent control and Nurr1-expressing NSC lines using Affymetrix cDNA microarrays. These data reveal the regulation of genes involved in promoting cell survival (trophic/growth factors and stress response genes) and in preventing cell death (decreased caspase-3 and caspase-11 expression). W ...[more]