Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Elphege Nora
PROVIDER: E-GEOD-35721 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nora Elphège P EP Lajoie Bryan R BR Schulz Edda G EG Giorgetti Luca L Okamoto Ikuhiro I Servant Nicolas N Piolot Tristan T van Berkum Nynke L NL Meisig Johannes J Sedat John J Gribnau Joost J Barillot Emmanuel E Blüthgen Nils N Dekker Job J Heard Edith E
Nature 20120411 7398
In eukaryotes transcriptional regulation often involves multiple long-range elements and is influenced by the genomic environment. A prime example of this concerns the mouse X-inactivation centre (Xic), which orchestrates the initiation of X-chromosome inactivation (XCI) by controlling the expression of the non-protein-coding Xist transcript. The extent of Xic sequences required for the proper regulation of Xist remains unknown. Here we use chromosome conformation capture carbon-copy (5C) and su ...[more]