Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human CaCo-2 cells following various iron treatments


ABSTRACT: We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Experiment Overall Design: Biological replicates were used (3 samples) of each iron treatments (SF-FAC, SF-0, DMEM-FBS, DMEM-Hemin). Each sample was labelled with cy5 and a pool of each sample was constituted and labelled with cy3.

ORGANISM(S): Homo sapiens

SUBMITTER: chicault celine 

PROVIDER: E-GEOD-3573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Iron-related transcriptomic variations in CaCo-2 cells, an in vitro model of intestinal absorptive cells.

Chicault Céline C   Toutain Bertrand B   Monnier Annabelle A   Aubry Marc M   Fergelot Patricia P   Le Treut Andre A   Galibert Marie-Dominique MD   Mosser Jean J  

Physiological genomics 20060425 1


Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose, we used a global transcriptomic approach, using the CaCo-2 cell line as an in vitro model of intestinal absorptive cells. Pangenomic screening for variations in gene expression cor  ...[more]

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