DNA microarray analysis of genes positively regulated by HapR
Ontology highlight
ABSTRACT:
ORGANISM(S): Vibrio cholerae
SUBMITTER: Melanie Blokesch
PROVIDER: E-GEOD-3576 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Chitin induces natural competence in Vibrio cholerae.
Meibom Karin L KL Blokesch Melanie M Dolganov Nadia A NA Wu Cheng-Yen CY Schoolnik Gary K GK
Science (New York, N.Y.) 20051201 5755
The mosaic-structured Vibrio cholerae genome points to the importance of horizontal gene transfer (HGT) in the evolution of this human pathogen. We showed that V. cholerae can acquire new genetic material by natural transformation during growth on chitin, a biopolymer that is abundant in aquatic habitats (e.g., from crustacean exoskeletons), where it lives as an autochthonous microbe. Transformation competence was found to require a type IV pilus assembly complex, a putative DNA binding protein, ...[more]
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