Unknown,Transcriptomics,Genomics,Proteomics

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Suppression of the antiviral response by an influenza "histone mimic"


ABSTRACT: Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 target the transcription elongation PAF1 complex (hPAF1C). We demonstrate that binding of NS1 to hPAF1C results in suppression of hPAF1C-mediated transcriptional elongation. In the following data sets, we show that NS1 colocalizes with hPAF1 on the chromatin of infected cells and that siRNA-mediated reduction of hPAF1 expression results in reduced recruitment of NS1 to the chromatin. Examination of different histone modifications in infected cells and RNA-Seq and GRO-Seq transcript measurements.

ORGANISM(S): Homo sapiens

SUBMITTER: ivan marazzi 

PROVIDER: E-GEOD-35774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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