Natural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Casey Romanoski
PROVIDER: E-GEOD-46494 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Effect of natural genetic variation on enhancer selection and function.
Heinz S S Romanoski C E CE Benner C C Allison K A KA Kaikkonen M U MU Orozco L D LD Glass C K CK
Nature 20131013 7477
The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of sequence variation on lineage-determining and signal-specific transcription factor binding, epigenomics and transcriptional outcomes in primary macrophages from different mouse strains. We find substantial genetic evidence to support the concept tha ...[more]
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