Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Tiandao Li
PROVIDER: E-GEOD-35886 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cheng Bo B Li Tiandao T Rahl Peter B PB Adamson Todd E TE Loudas Nicholas B NB Guo Jiannan J Varzavand Katayoun K Cooper Jeffrey J JJ Hu Xiaopeng X Gnatt Averell A Young Richard A RA Price David H DH
Molecular cell 20120101 1
Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. We present evidence that Gdown1, the product of the POLR2M gene that renders Pol II responsive to Mediator, is involved in Pol II elongation control. During in vitro transcription, Gdown1 specifically blocked elongation stimulation by TFIIF, inhibited the termination activity of TTF2, and influenced pausing factors NELF and DSIF, but d ...[more]