Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Renormalization of GSE32442 and GSE33128 plus 1 control sample


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE35878: Renormalization of GSE32442 and GSE33128 GSE35882: Whole Cell Extract Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Tiandao Li 

PROVIDER: E-GEOD-35886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. We present evidence that Gdown1, the product of the POLR2M gene that renders Pol II responsive to Mediator, is involved in Pol II elongation control. During in vitro transcription, Gdown1 specifically blocked elongation stimulation by TFIIF, inhibited the termination activity of TTF2, and influenced pausing factors NELF and DSIF, but d  ...[more]

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