Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human early stage non-small cell lung carcinoma to refine prognosis for adjuvant therapy


ABSTRACT: Abstract from paper - Potti A, et al Experiment Overall Design: Retrospective analysis of approximately 200 samples obtained from Duke, ACOSOG and CALGB to develop a Lung metagene predictor that would then be used to assess risk of recurrence and thus identify high risk patients with stage Ia non-small cell carcinoma who would be candidates for adjuvant chemotherapy

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Nevins 

PROVIDER: E-GEOD-3593 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>Clinical trials have indicated a benefit of adjuvant chemotherapy for patients with stage IB, II, or IIIA--but not stage IA--non-small-cell lung cancer (NSCLC). This classification scheme is probably an imprecise predictor of the prognosis of an individual patient. Indeed, approximately 25 percent of patients with stage IA disease have a recurrence after surgery, suggesting the need to identify patients in this subgroup for more effective therapy.<h4>Methods</h4>We identified  ...[more]

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