Proteomics

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Adjuvant Secretomes - Adjuvant-induced human monocyte secretome profiles reveal adjuvant- and age-specific protein signatures

ABSTRACT: Adjuvant-induced human monocyte secretome profiles reveal adjuvant- and age-specific protein signatures.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Disease Free

SUBMITTER: Sebastian Berger  

LAB HEAD: Hanno Steen, Ofer Levy

PROVIDER: PXD003534 | Pride | 2016-03-14

REPOSITORIES: Pride

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Dataset's files

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DYO-HS_EXP9_A1 (Exp9_A1_F019109).mzid_DYO-HS_EXP9_A1_(Exp9_A1_F019109).pride.mgf.gz Mzid
DYO-HS_EXP9_A1 (Exp9_A1_F019109).pride.mztab.gz Mztab
DYO-HS_EXP9_A1.raw Raw
DYO-HS_EXP9_A1Exp9_A1_F019109.mzid.gz Mzid
DYO-HS_EXP9_A1Exp9_A1_F019109.mzid_DYO-HS_EXP9_A1_Exp9_A1_F019109.MGF Mzid
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Publications

Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.

Oh Djin-Ye DY   Dowling David J DJ   Ahmed Saima S   Choi Hyungwon H   Brightman Spencer S   Bergelson Ilana I   Berger Sebastian T ST   Sauld John F JF   Pettengill Matthew M   Kho Alvin T AT   Pollack Henry J HJ   Steen Hanno H   Levy Ofer O  

Molecular & cellular proteomics : MCP 20160301 6

Adjuvants boost vaccine responses, enhancing protective immunity against infections that are most common among the very young. Many adjuvants activate innate immunity, some via Toll-Like Receptors (TLRs), whose activities varies with age. Accordingly, characterization of age-specific adjuvant-induced immune responses may inform rational adjuvant design targeting vulnerable populations. In this study, we employed proteomics to characterize the adjuvant-induced changes of secretomes from human new  ...[more]

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