RNA-Sequencing from ventral mid brain and striatum of paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Seema Gollamudi
PROVIDER: E-GEOD-36232 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
Gollamudi Seema S Johri Ashu A Calingasan Noel Y NY Yang Lichuan L Elemento Olivier O Beal M Flint MF
PloS one 20120501 5
Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most widely used pesticides. We studied mRNA expression using transcriptome sequencing (RNA-Seq) in the ventral midbrain (VMB) and striatum (STR) of PQ, PY and paraquat+maneb (MNPQ) treated mice, followed by pathway analysis. We found concordance of signaling pathw ...[more]
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