Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Yijun Qi
PROVIDER: E-GEOD-36338 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wei Wei W Ba Zhaoqing Z Gao Min M Wu Yang Y Ma Yanting Y Amiard Simon S White Charles I CI Rendtlew Danielsen Jannie Michaela JM Yang Yun-Gui YG Qi Yijun Y
Cell 20120322 1
Eukaryotes have evolved complex mechanisms to repair DNA double-strand breaks (DSBs) through coordinated actions of protein sensors, transducers, and effectors. Here we show that ∼21-nucleotide small RNAs are produced from the sequences in the vicinity of DSB sites in Arabidopsis and in human cells. We refer to these as diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the PI3 kinase ATR, RNA polymerase IV (Pol IV), and Dicer-like proteins. Mutations in these p ...[more]