Transcriptomics

Dataset Information

0

Investigating the role of Dicer-dependent transfer RNA-derived small RNAs in gene expression regulation


ABSTRACT: We used sequencing analyses to identify small RNAs that are generated in a Dicer-dependent manner and the genes that are dysregulated upon Dicer knockdown at the mRNA level, and upon Drosha, Dicer and Ago2 knockdown at the chromatin level in HEK293 cells. We found that levels of tRNA-derived sRNAs decreased alongside microRNAs upon Dicer knockdown. Many genes are dysregulated at the chromatin levels when Dicer and Ago2 levels are reduced, indicating that Dicer and Ago2 can regulate genes directly or indirectly at the transcriptional level. Drosha knockdown, on the other hand, has a marginal effect on RNA levels at the chromatin.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126751 | GEO | 2022/02/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2009-01-15 | E-GEOD-13640 | biostudies-arrayexpress
2015-05-17 | GSE68813 | GEO
2015-05-17 | E-GEOD-68813 | biostudies-arrayexpress
2015-09-30 | GSE67992 | GEO
| PRJNA113875 | ENA
2013-10-21 | E-GEOD-48160 | biostudies-arrayexpress
2013-12-31 | GSE47519 | GEO
2013-10-21 | GSE48158 | GEO
2013-10-21 | GSE48160 | GEO
2024-08-01 | GSE211711 | GEO