Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Evert van Schothorst
PROVIDER: E-GEOD-36718 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Horakova Olga O Medrikova Dasa D van Schothorst Evert M EM Bunschoten Annelies A Flachs Pavel P Kus Vladimir V Kuda Ondrej O Bardova Kristina K Janovska Petra P Hensler Michal M Rossmeisl Martin M Wang-Sattler Rui R Prehn Cornelia C Adamski Jerzy J Illig Thomas T Keijer Jaap J Kopecky Jan J
PloS one 20120831 8
Insulin resistance, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. This, in turn, contributes to a further damage of insulin signaling. Effectiveness of T2D treatment depends in large part on the improvement of insulin sensitivity and metabolic adaptability of the muscle, the main site of whole-body glucose utilization. We have shown previously in mice fed an obesogenic high-fat diet that a c ...[more]