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MicroRNA profiling in paired human prostate cancer and benign prostate tissue

ABSTRACT: To determine the altered microRNA expression signature in human prostate cancer compared to benign prostate tissue. To determine the altered mRNA expression signatures upon overexrpession miR-31 in prostate cancer cells. Two condition experiments:1) Total RNA from 21 pairs of prostate cancers and matched benign prostate tissues were collected and processed for microRNA detection. 2) In LNCaP prostate cancer cells, miR-31 was overexpressed and compared to control miR-NC.

ORGANISM(S): Homo sapiens

SUBMITTER: Pei-Chun Lin

PROVIDER: E-GEOD-36802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.

Lin Pei-Chun PC Chiu Ya-Lin YL Banerjee Samprit S Park Kyung K Mosquera Juan Miguel JM Giannopoulou Eugenia E Alves Pedro P Tewari Ashutosh K AK Gerstein Mark B MB Beltran Himisha H Melnick Ari M AM Elemento Olivier O Demichelis Francesca F Rubin Mark A MA

Cancer research 20121211 3

Androgen receptor signaling plays a critical role in prostate cancer pathogenesis. Yet, the regulation of androgen receptor signaling remains elusive. Even with stringent androgen deprivation therapy, androgen receptor signaling persists. Here, our data suggest that there is a complex interaction between the expression of the tumor suppressor miRNA, miR-31, and androgen receptor signaling. We examined primary and metastatic prostate cancer and found that miR-31 expression was reduced as a result ...[more]

PMID: 23233736

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