Genome-wide gene expression patterns comparing various pluripotent stem cells.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nobuaki Kikyo
PROVIDER: E-GEOD-37077 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Establishment of LIF-dependent human iPS cells closely related to basic FGF-dependent authentic iPS cells.
Hirai Hiroyuki H Firpo Meri M Kikyo Nobuaki N
PloS one 20120613 6
Human induced pluripotent stem cells (iPSCs) can be divided into a leukemia inhibitory factor (LIF)-dependent naïve type and a basic fibroblast growth factor (bFGF)-dependent primed type. Although the former are more undifferentiated than the latter, they require signal transduction inhibitors and sustained expression of the transgenes used for iPSC production. We used a transcriptionally enhanced version of OCT4 to establish LIF-dependent human iPSCs without the use of inhibitors and sustained ...[more]
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