Unknown,Transcriptomics,Genomics,Proteomics

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Bronchial airway gene expression reflects a COPD-associated field of injury that changes with disease severity and is reversible with therapy


ABSTRACT: RNA was isolated from bronchial brushings obtained from current and former smokers with and without COPD. mRNA expression was profiled using Affymetrix Human Gene 1.0 ST Arrays. RNA isolated from bronchial brushings was processed and hybridized to Affymetrix Human Gene 1.0 ST Arrays. A total of 269 arrays from 267 subjects were hybridized. Data from the 269 microarrays were used for RMA normalization. Data from 238 subjects was used in the analysis to determine the association of gene expression with COPD-related phenotypes.

ORGANISM(S): Homo sapiens

SUBMITTER: Katrina Steiling 

PROVIDER: E-GEOD-37147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Rationale</h4>Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function.<h4>Objectives</h4>We sought to determine whether COPD-associated processes are reflected in gene expression profiles of bronchial airway epithelial cells obtained by bronchoscopy.<h4>Methods</h4>Gene expression profiling of bronchial brushings obtained from 238 current and former smokers w  ...[more]

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