Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wan Lam
PROVIDER: E-GEOD-56341 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vucic Emily A EA Chari Raj R Thu Kelsie L KL Wilson Ian M IM Cotton Allison M AM Kennett Jennifer Y JY Zhang May M Lonergan Kim M KM Steiling Katrina K Brown Carolyn J CJ McWilliams Annette A Ohtani Keishi K Lenburg Marc E ME Sin Don D DD Spira Avrum A Macaulay Calum E CE Lam Stephen S Lam Wan L WL
American journal of respiratory cell and molecular biology 20140501 5
DNA methylation is an epigenetic modification that is highly disrupted in response to cigarette smoke and involved in a wide spectrum of malignant and nonmalignant diseases, but surprisingly not previously assessed in small airways of patients with chronic obstructive pulmonary disease (COPD). Small airways are the primary sites of airflow obstruction in COPD. We sought to determine whether DNA methylation patterns are disrupted in small airway epithelia of patients with COPD, and evaluate wheth ...[more]