Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of COPD and nonCOPD small airway epithelia


ABSTRACT: Gene expression profiles in this submission were part of an integrative DNA methylation and gene expression integrative study. The goal of this study was to determine whether DNA methylation patterns were disrupted in small airway epithelia of patients with Chronic Obstructive Pulmonary Disease (COPD) compared to airways from subjects with normal lung function. No subject has cancer or asthma at time of collection. Corresponding DNA methylation profiles for these subjects can be found at GSE55454. We concluded that methylation alterations in COPD airways may underlie disease-specific gene-expression changes (such as the Nrf2 oxidative response pathway). RNA isolated from bronchial brushings was processed and hybridized to Affymetrix Human Gene 1.0 ST Arrays. DNA isolated from these same samples can be found at GSE55454

ORGANISM(S): Homo sapiens

SUBMITTER: Wan Lam 

PROVIDER: E-GEOD-56341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.

Vucic Emily A EA   Chari Raj R   Thu Kelsie L KL   Wilson Ian M IM   Cotton Allison M AM   Kennett Jennifer Y JY   Zhang May M   Lonergan Kim M KM   Steiling Katrina K   Brown Carolyn J CJ   McWilliams Annette A   Ohtani Keishi K   Lenburg Marc E ME   Sin Don D DD   Spira Avrum A   Macaulay Calum E CE   Lam Stephen S   Lam Wan L WL  

American journal of respiratory cell and molecular biology 20140501 5


DNA methylation is an epigenetic modification that is highly disrupted in response to cigarette smoke and involved in a wide spectrum of malignant and nonmalignant diseases, but surprisingly not previously assessed in small airways of patients with chronic obstructive pulmonary disease (COPD). Small airways are the primary sites of airflow obstruction in COPD. We sought to determine whether DNA methylation patterns are disrupted in small airway epithelia of patients with COPD, and evaluate wheth  ...[more]

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