Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Julia Charles
PROVIDER: E-GEOD-37219 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Aliprantis Antonios O AO Ueki Yasuyoshi Y Sulyanto Rosalyn R Park Arnold A Sigrist Kirsten S KS Sharma Sudarshana M SM Ostrowski Michael C MC Olsen Bjorn R BR Glimcher Laurie H LH
The Journal of clinical investigation 20081009 11
Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid precursors in response to the cytokine RANKL. To gain insight into the transcriptional regulation of bone resorption during growth and disease, we generated a conditional knockout of the transcription factor nuclear factor of activated T cells c1 (Nfatc1). Deletion of Nfatc1 in young mice resulted in osteopetrosis ...[more]