Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Impact of Elevated Plasma 5-HT on Global Gene Expression of Murine Megakaryocytes


ABSTRACT: The goal of this project was to understand the functional consequences of plasma biogenic amine serotonin (5-HT) elevation in megakaryocytes by measuring gene expression Total RNA was extracted from the megakaryocytes of mice treated with either 5-HT or saline and global gene expression was measured.

ORGANISM(S): Mus musculus

SUBMITTER: fusun kilic 

PROVIDER: E-GEOD-37273 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Impact of elevated plasma serotonin on global gene expression of murine megakaryocytes.

Mercado Charles P CP   Byrum Stephanie S   Beggs Marjorie L ML   Ziu Endrit E   Singh Preeti P   Raj Vinay R VR   Haun Randy S RS   Kilic Fusun F  

PloS one 20130827 8


<h4>Background</h4>Serotonin (5-HT) is a biogenic amine that also acts as a mitogen and a developmental signal early in rodent embryogenesis. Genetic and pharmacological disruption of 5-HT signaling causes various diseases and disorders via mediating central nervous system, cardiovascular system, and serious abnormalities on a growing embryo. Today, neither the effective modulators on 5-HT signaling pathways nor the genes affected by 5-HT signal are well known yet.<h4>Methodology/principal findi  ...[more]

Similar Datasets

2014-04-04 | GSE37273 | GEO
2014-07-28 | E-GEOD-42110 | biostudies-arrayexpress
2023-07-01 | E-MTAB-11960 | biostudies-arrayexpress
2008-07-29 | E-GEOD-12234 | biostudies-arrayexpress
2007-02-02 | E-GEOD-6940 | biostudies-arrayexpress
2008-06-16 | E-GEOD-9218 | biostudies-arrayexpress
2007-12-07 | E-GEOD-4479 | biostudies-arrayexpress
2017-10-05 | PXD005834 | Pride
2015-06-30 | E-GEOD-57455 | biostudies-arrayexpress
| PRJNA159221 | ENA