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MiR-23b suppresses IL-17 associated autoimmune pathogenesis

ABSTRACT: MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease states, including inflammatory autoimmune diseases. By using high-throughput microRNA profiling analysis, we identified a series of miRNAs dysregulated in local inflammatory lesions of human patients with autoimmune diseases such as SLE. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Nan Shen

PROVIDER: E-GEOD-37276 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.

Zhu Shu S Pan Wen W Song Xinyang X Liu Yan Y Shao Xinrui X Tang Yuanjia Y Liang Dong D He Dongyi D Wang Honglin H Liu Wenjun W Shi Yufang Y Harley John B JB Shen Nan N Qian Youcun Y

Nature medicine 20120701 7

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune pathogenesis by affecting lymphocyte development and function, the role of miRNAs in resident cells present in inflammatory lesions remains unclear. Here we show that miR-23b is downregulated in inflammatory lesions of humans with lupus or rheumatoid arthritis, as well as in the mouse models of lupus, rheumatoid arthritis or mu ...[more]

PMID: 22660635

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