Replicative senescence in human fibroblasts
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hong Zhang
PROVIDER: E-GEOD-3730 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci.
Zhang Hong H Pan Kuang-Hung KH Cohen Stanley N SN
Proceedings of the National Academy of Sciences of the United States of America 20030307 6
Replicative senescence is the state of irreversible proliferative arrest that occurs as a concomitant of progressive telomere shortening. By using cDNA microarrays and the gabriel system of computer programs to apply domain-specific and procedural knowledge for data analysis, we investigated global changes in gene transcription occurring during replicative senescence in human fibroblasts and mammary epithelial cells (HMECs). Here we report the identification of transcriptional "fingerprints" uni ...[more]
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