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Androgen receptor-independent function of FoxA1 in prostate cancer metastasis

ABSTRACT: FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore, the role of FoxA1 itself in prostate cancer has not been carefully examined. Thus, it is important to understand the role of FoxA1 in prostate cancer and how it interacts with AR signaling. To address these questions, we generated engineered LNCaP cells with FoxA1 knockdown using shRNA or siRNA, 22RV1 cells with stable FoxA1 knockdown and PC3M cells with FoxA1 stable overexpression. We performed microarray analysis of these cells. We performed microarray analysis on LNCaP cells with FoxA1 knockdown using shRNA or siRNA, 22RV1 cells with stable FoxA1 knockdown and PC3M cells with FoxA1 stable overexpression

ORGANISM(S): Homo sapiens

SUBMITTER: Hong-Jian Jin

PROVIDER: E-GEOD-37314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Androgen receptor-independent function of FoxA1 in prostate cancer metastasis.

Jin Hong-Jian HJ Zhao Jonathan C JC Ogden Irene I Bergan Raymond C RC Yu Jindan J

Cancer research 20130328 12

FoxA1 (FOXA1) is a pioneering transcription factor of the androgen receptor (AR) that is indispensible for the lineage-specific gene expression of the prostate. To date, there have been conflicting reports on the role of FoxA1 in prostate cancer progression and prognosis. With recent discoveries of recurrent FoxA1 mutations in human prostate tumors, comprehensive understanding of FoxA1 function has become very important. Here, through genomic analysis, we reveal that FoxA1 regulates two distinct ...[more]

PMID: 23539448

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