Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jindan Yu
PROVIDER: E-GEOD-69045 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhao J C JC Fong K-W KW Jin H-J HJ Yang Y A YA Kim J J Yu J J
Oncogene 20160111 33
Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer. Here, we examined how FOXA1, GATA2 and AR crosstalk and regulate hormone-dependent gene expression in prostate cancer cells. Chromatin immunoprecipitation sequencing analysis revealed that FOXA1 reprograms both AR and GATA2 cistrome by prefe ...[more]