Unknown,Transcriptomics,Genomics,Proteomics

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The Caucasus as an asymmetric semipermeable barrier to ancient human migrations

ABSTRACT: The Caucasus, inhabited by modern humans since the Early Upper Paleolithic and known for its linguistic diversity, is considered to be important for understanding human dispersals and genetic diversity in Eurasia. We report a synthesis of autosomal, Y chromosome, and mitochondrial DNA (mtDNA) variation in populations from all major subregions and linguistic phyla of the area. Autosomal genome variation in the Caucasus reveals significant genetic uniformity among its ethnically and linguistically diverse populations and is consistent with predominantly Near/Middle Eastern origin of the Caucasians, with minor external impacts. In contrast to autosomal and mtDNA variation, signals of regional Y chromosome founder effects distinguish the eastern from western North Caucasians. Genetic discontinuity between the North Caucasus and the East European Plain contrasts with continuity through Anatolia and the Balkans, suggesting major routes of ancient gene flows and admixture. 204 samples were analysed with the Illumina platform Human610-Quad v 1.0 and are described herein.

ORGANISM(S): Homo sapiens

SUBMITTER: Mait Metspalu

PROVIDER: E-GEOD-37342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Caucasus as an asymmetric semipermeable barrier to ancient human migrations.

Yunusbayev Bayazit B Metspalu Mait M Järve Mari M Kutuev Ildus I Rootsi Siiri S Metspalu Ene E Behar Doron M DM Varendi Kärt K Sahakyan Hovhannes H Khusainova Rita R Yepiskoposyan Levon L Khusnutdinova Elza K EK Underhill Peter A PA Kivisild Toomas T Villems Richard R

Molecular biology and evolution 20110913 1

The Caucasus, inhabited by modern humans since the Early Upper Paleolithic and known for its linguistic diversity, is considered to be important for understanding human dispersals and genetic diversity in Eurasia. We report a synthesis of autosomal, Y chromosome, and mitochondrial DNA (mtDNA) variation in populations from all major subregions and linguistic phyla of the area. Autosomal genome variation in the Caucasus reveals significant genetic uniformity among its ethnically and linguistically ...[more]

PMID: 21917723

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Dataset Information

The Caucasus as an asymmetric semipermeable barrier to ancient human migrations

Publications

The Caucasus as an asymmetric semipermeable barrier to ancient human migrations.

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