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Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice


ABSTRACT: We previously showed that a diet containing phloridzin suppressed the blood glucose levels in streptozotocin-induced diabetic mice most likely by inhibiting glucose absorption from the small intestine. In this study, we showed that 0.5% and 1% phloridzin diets significantly reduce the blood glucose levels in healthy normal BALB/c mice after 7 days of feeding. To understand the effect of the high continuing intake of dietary phloridzin on normal mouse livers, we analyzed the hepatic gene expressions in mice fed diets containing 0%, 0.1%, 0.5%, or 1% phloridzin for 14 days using DNA microarrays. Six-week-old male mice were divided into 4 groups of 6 mice each, housed in groups of 3 per cage, and fed a standard purified AIN-93G diet containing 0% (Con), 0.1% (Phlorizin0.1), 0.5% (Phlorizin0.5), or 1% phloridzin (purity > 97%) (Phlorizin1.0) for 2 weeks.

ORGANISM(S): Mus musculus

SUBMITTER: Masuko Kobori 

PROVIDER: E-GEOD-37415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice.

Kobori Masuko M   Masumoto Saeko S   Akimoto Yukari Y   Oike Hideaki H  

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120417 7


We previously showed that a diet containing phloridzin suppressed the blood glucose levels in streptozotocin-induced diabetic mice most likely by inhibiting glucose absorption from the small intestine. In this study, we showed that 0.5% and 1% phloridzin diets significantly reduce the blood glucose levels in healthy normal BALB/c mice after 7 days of feeding. The 0.1% phloridzin diet did not suppress blood glucose levels but induced the alteration of the hepatic gene expressions related to carbo  ...[more]

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