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Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Viji Nair

PROVIDER: E-GEOD-37463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Berthier Celine C CC Bethunaickan Ramalingam R Gonzalez-Rivera Tania T Nair Viji V Ramanujam Meera M Zhang Weijia W Bottinger Erwin P EP Segerer Stephan S Lindenmeyer Maja M Cohen Clemens D CD Davidson Anne A Kretzler Matthias M

Journal of immunology (Baltimore, Md. : 1950) 20120620 2

Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these preclinical models. In this study, we used an unbiased transcriptional network approach to define, in molecular terms, similarities and differences among three lupus models and human LN. Genome-wide gene-expression networks were generated using natural language proces ...[more]

PMID: 22723521

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